Yagmur, YOzturk, HUnaldi, MGedik, E2024-04-242024-04-2420050014-312X1421-9921https://doi.org/10.1159/000090337https://hdl.handle.net/11468/1794440th Congress of the European-Society-for-Surgical-Research -- MAY 25-28, 2005 -- Konya, TURKEYThe aim of this study was to evaluate the relation between severity of injury and the early activation of interleukins in multiple-injured patients. Ninety-nine patients with multiple injuries were included in this prospective study. Plasma levels of interleukin (IL)-1, IL-2, IL-6, IL-8 and TNF-alpha were measured. Injury Severity Score ( ISS), Revised Trauma Score (RTS), Glasgow Coma Score (GCS) and the Acute Physiology and Chronic Health Evaluation II (APACHE- II) were all recorded. Of the 99 patients, 82 were male and 17 were female. The mean age was 26.6 +/- 20.7 years. The mortality rate for this series was 17%. Patients who died from trauma exhibited a significant increase for IL-2, IL-6 and IL-8 in comparison with patients who survived. Significant differences for ISS, RTS and GCS were found between survivors and non-survivors. Values in all patients with ISS 1 16 were increased and these increases were significant for IL-6 and IL-2. These data show that the initial increase of IL-2, IL-6 and IL-8 might predict the patients with a high possibility of mortality and a significant increase of IL-2 and IL-6 in patients with ISS > 16 might be used in a new developed trauma score combined with ISS as an indicator for the injury severity. Copyright (C) 2005 S. Karger AG, Basel.eninfo:eu-repo/semantics/closedAccessMultiple-Injured PatientsCytokinesMortalityConference Object376360364WOS:0002352094000082-s2.0-322444352411646506110.1159/000090337Q2Q3