Trauma Scores and Neuron-specific Enolase, Cytokine and C-reactive Protein Levels as Predictors of Mortality in Patients with Blunt Head Trauma

Sogut, O.Guloglu, C.Orak, M.Sayhan, M. B.Gokdemir, M. T.Ustundag, M.Akkus, Z.2024-04-242024-04-2420100300-06051473-2300https://doi.org/10.1177/147323001003800516https://hdl.handle.net/11468/18157This study evaluated serum neuron-specific enolase (NSE), cytokine and high-sensitivity C-reactive-protein (hs-CRP) levels, along with the Glasgow Coma Scale (GCS) and Revised Trauma Score (RTS), as predictors of mortality in the early post-traumatic period, in 100 Turkish patients with blunt head trauma. Overall patient mortality was 27%. There was a significant association between age and mortality, and mortality was negatively correlated with GCS and RTS. Head injury severity (GCS) was significantly related to NSE, hs-CRP, interleukin (IL)-6, IL-8 and tumour necrosis factor (TNF)-alpha levels. Mortality correlated positively with IL-6, IL-8, TNF-alpha and hs-CRP levels. NSE, hs-CRP, IL-6, IL-8 and TNF-alpha levels were significantly higher in non-survivors compared with survivors. GCS score <= 8, younger age and NSE levels were significant independent predictors of mortality. During the early post-traumatic period, NSE may be an objective alternative criterion to the GCS, in the management of patients with blunt head trauma.eninfo:eu-repo/semantics/openAccessBlunt Head TraumaNeuron-Specific EnolaseCytokinesC-Reactive ProteinGlasgow Coma ScaleRevised Trauma ScoreTrauma Scores and Neuron-specific Enolase, Cytokine and C-reactive Protein Levels as Predictors of Mortality in Patients with Blunt Head TraumaTrauma Scores and Neuron-specific Enolase, Cytokine and C-reactive Protein Levels as Predictors of Mortality in Patients with Blunt Head TraumaArticle38517081720WOS:0002854040000162-s2.0-784492910372130948510.1177/147323001003800516Q2Q4