Karahan, MineHazar, LeylaErdem, SeyfettinAva, SedatDursun, Mehmet EminDemirtaş, Atılım ArmaǧanKeklikçi, Uğur2024-04-242024-04-242021Karahan, M., Hazar, L., Erdem, S., Ava, S., Dursun, M. E., Demirtaş, A. A. ve diğerleri. (2021). Is there a relationship between hematological inflammatory parameters and age-related macular degeneration?. Therapeutic Advances in Ophthalmology, 13, 1-7.2515-8414https://doi.org/10.1177/25158414211010550https://hdl.handle.net/11468/23571Purpose: We aimed to analyze blood inflammation parameters in patients with age-related macular degeneration (AMD). Methods: In this retrospective study, patients were divided into three groups: wet-type AMD (n = 60), dry-type AMD (n = 60), and healthy controls (n = 71). The laboratory and demographic data of the patients were analyzed. Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR) were calculated manually. Results: The mean NLR was 2.26 ± 1.42 in the dry-type AMD group, 3.90 ± 1.65 in the wet-type AMD group, and 1.84 ± 0.61 in the control group (p < 0.001). The mean MLR was 0.30 ± 0.20 in the dry-type AMD group, 0.47 ± 0.31 in the wet-type AMD group, and 0.28 ± 0.14 in the control group (p < 0.001). The mean PLR was 129.31 ± 79.82 in the dry-type AMD group, 156.67 ± 83.99 in the wet-type AMD group, and 135.59 ± 58.68 in the control group (p = 0.101). Receiver operating characteristic (ROC) curve analyses revealed that the area under the curve (AUC) for NLR and MLR was 0.920 and 0.717, respectively, for wet-type AMD. The sensitivity and specificity of NLR for wet-type AMD were 64% and 93%, respectively, whereas MLR was 63% and 75%, respectively. Conclusion: Simple blood tests revealed that NLR and MLR were significantly higher in patients with wet-type AMD than in patients with dry-type AMD and healthy controls, which implies low-grade inflammation.eninfo:eu-repo/semantics/openAccessAge-related macular degenerationMonocyte-to-lymphocyte ratioNeutrophil-to-lymphocyte ratioPlatelet-to-lymphocyte ratioIs there a relationship between hematological inflammatory parameters and age-related macular degeneration?Is there a relationship between hematological inflammatory parameters and age-related macular degeneration?Article132-s2.0-8512475717410.1177/25158414211010550Q1