Bozdaǧ, ZübeyirGümüş, MetehanArıkanoğlu, Zülfüİbiloğlu, İbrahimKaya, SavașEvliyaoǧlu, Osman2024-04-242024-04-242015Bozdaǧ, Z., Gümüş, M., Arıkanoğlu, Z., İbiloğlu, İ., Kaya, S. ve Evliyaoǧlu, O. (2015). Effect of intraperitoneal thymoquinone on postoperative peritoneal adhesions. Acta Chirurgica Belgica, 115(5), 364-368.0001-5458https://doi.org/10.1080/00015458.2015.11681129https://hdl.handle.net/11468/23396https://www.tandfonline.com/doi/abs/10.1080/00015458.2015.11681129Background: To determine the effect of thymoquinone on adhesion formation in a rat caecotomy/suture model. Materials and Methods: Thirty wistar rats were randomized into three groups: The control group received saline and the thymoquinone group received 10 mg/kg thymoquinone after cecal caecotomy/suture model. In the sham group the abdominal wall was closed without any abrasion to the cecum. On day 15, adhesions were classified, and histopathological samples were taken. Results: There were no incisional hernias or wound dehiscences. In comparing adhesion scores, a significant difference was found between the thymoquinone and the control groups (p < 0.05). The grade of inflammation for the thymoquinone and the sham groups were significantly lower than that of the control group (p < 0.01 and p < 0.001, respectively). Hydroxyproline levels were significantly lower in the sham and thymoquinone groups compared to the control group (p < 0.05). Conclusions: Based on the results of this study in a rat peritoneal adhesion model, intraperitoneal administered thymoquinone has a strong anti-adhesive effect.eninfo:eu-repo/semantics/closedAccessArticle11553643682-s2.0-849574154852656000310.1080/00015458.2015.11681129Q3