Öcal, EceAkalin, SenemDeveci, Engin2025-02-222025-02-2220232687-4555https://doi.org/10.37990/medr.1252256https://search.trdizin.gov.tr/tr/yayin/detay/1263417https://hdl.handle.net/11468/30038Aim: In this study, we investigated the immunohistochemical staining of Sox-9 and Caspase-6 expression in placentas of pregnant woman with gestational diabetes mellitus (GDM). Material and Methods: Placentas of 20 healthy and 20 women with GDM were processed for routine histological tissue processing. The biochemical and clinical parameters of patients were recorded. Placentas were stained with hematoxylin-eosin and Sox-9 and Caspase-6 immunostaining. Results: In control group, Sox-9 expression was negative in decidual and connective cells and endothelial cells. In GDM group, Sox-9 expression was increased especially in the decidual cells. For the Caspase-6 expression, Caspase-6 reaction was mainly in maternal region in control group. In GDM group, Caspase-6 reaction was increased in decidual cells, in endothelial cells and in the syncytial nodes. Conclusion: Expression of Sox-9 transformed the decidua cells and lead to apoptotic pathway via Caspase-6 expression.eninfo:eu-repo/semantics/openAccessGDMplacentaSox-9caspase-6Article53445448126341710.37990/medr.1252256