Ak, BunyaminAydemir, MuratDurap, FeyyazMeric, NerminBaysal, Akin2024-04-242024-04-2420150020-16931873-3255https://doi.org/10.1016/j.ica.2015.09.003https://hdl.handle.net/11468/15462Homogeneous catalysis has been responsible for many major recent developments in synthetic organic chemistry. The combined use of organometallic and coordination chemistry has produced a number of new and powerful synthetic methods for important classes of compounds in general and for optically active substances in particular. For this aim, a new class of chiral modular C-2-symmetric ferrocenyl phosphinite ligands has been prepared in good yields by using the inexpensive 1,1'-ferrocenedicarboxyaldehyde and various ferrocene based-amino alcohols as starting materials, and applied in the rhodium(I)-catalyzed asymmetric transfer hydrogenation (ATH) of aromatic ketones to give corresponding secondary alcohols with excellent enantioselectivities and reactivities using isoPrOH as the hydrogen source (up to 99% conversion and 99% ee). The substituents on the backbone of the ligands are found to exhibit a remarkable effect on both the activity and % ee. The structures of these ligands and their complexes have been elucidated by a combination of multinuclear NMR spectroscopy, IR spectroscopy and elemental analysis. (C) 2015 Elsevier B.V. All rights reserved.eninfo:eu-repo/semantics/closedAccessAsymmetric CatalysisC-2-Symmetric Ferrocenyl PhosphiniteAsymmetric Transfer HydrogenationAromatic KetonesRhodium(I)Article4384251WOS:0003638675000082-s2.0-8494262674810.1016/j.ica.2015.09.003Q2Q2