Ünal, EdipPirinççioğlu, Ayfer GözüYanmaz, Sercan YücelYılmaz, KamilTaşkesen, MustafaHaspolat, Yusuf Kenan2021-11-302021-11-302020Ünal, E., Pirinççioğlu, A. G., Yanmaz, S. Y., Yılmaz, K., Taşkesen, M., Haspolat, Y. K. ve diğerleri. (2020).A different perspective of elevated lactace in pediatric patients with diabetic ketoacidosis. Acta Endocrinologica (Bucharest), 16(1), 114-117.https://pubmed.ncbi.nlm.nih.gov/32685051/https://hdl.handle.net/11468/8338Objective: This study aims to determine the frequency and prognostic significance of lactic acidosis in children with diabetic ketoacidosis (DKA) admitted to the pediatric intensive care unit. Methods: The study was carried out retrospectively by examining the patients admitted to the pediatric intensive care unit for the treatment of DKA. The ages of the patients ranged from 2 to 18 years. The patients with the following parameters were enrolled in the study: serum blood glucose>200 mg/dL, ketonuria presence, venous blood gas pH ≤7.1, bicarbonate <15. Results: A total of 56 patients were included in the study with a mean age of 111.07 ± 51.13 months. The recovery time from DKA was 16.05 ± 6.25 h in the group with low lactate level and it was 13.57 ± 8.34 h in the group with high lactate level with no statistically significant difference. There was a negative correlation between lactate levels and the recovery time from DKA. Conclusion: Lactic acidosis is common in DKA, and unlike other conditions, such as sepsis, it is not always a finding of poor prognosis that predicts the severity of the disease or mortality. We think that high lactate may even protect against possible brain edema-cerebral damage in DKA.eninfo:eu-repo/semantics/openAccessBrain edemaChildrenDiabetic ketoacidosisIntensive careLactateArticle161114117WOS:0005575836000212-s2.0-850906436513268505110.4183/aeb.2020.114N/AQ4