Erdoğmuş, ZozanGülsün, Belgin2022-10-032022-10-032021Erdoğmuş, Z. ve Gülsün, B. (2021). The effect of mesenchymal stem cells, demineralized bone graft and platelet-rich plasma on osteogenesis in rat tibia defects. International Dental Research, 11(Supplement 1), 47-55.2146-1767https://search.trdizin.gov.tr/yayin/detay/516626https://hdl.handle.net/11468/10600https://search.trdizin.gov.tr/yayin/detay/516626Aim: Deformities of the jaw and face are often caused by infection, inflammation, and cystic and neoplastic pathological conditions. Defects with various aetiologies should be repaired promptly using the most appropriate approach to reconstruct the anatomical form. To treat defects, bone grafts with various combinations have been used. In particular, combinations including cellular products to enhance osteogenic properties have been implemented. In this study, we aimed to investigate the effects of different materials and cells on bone defects by using mesenchymal stem cells (MSCs), which are thought to have a positive effect on healing, demineralized bone graft (DMB) and platelet-rich plasma (PRP). Methodology: We used 55 female rats weighing between 200-250 g, four of which were used to obtain platelet-rich plasma. The remaining animals were divided into five groups. Group I (n = 6) was the operative control group, Group II (n = 24) was given DMB, Group III (n = 24) was given DMB+PRP, Group IV (n = 24) was given MSC+DBG and Group V (n = 24) was given DMB+PRP+MSC applied to rat tibial defects (10 mm x 3 mm x 2 mm). Results: Statistically significant differences were observed in bone osteoblastic activity in tibia defects among the groups (p<0.05). Conclusion: Bone regeneration was significantly improved in groups where MSCs were used in combination with DMB and PRP.eninfo:eu-repo/semantics/openAccessBone defectDemineralized bone graftMesenchymal stem cellPlatelet rich plasmaRatArticle11Supplement 1475551662610.5577/intdentres.2021.vol11.suppl1.8