Ketan? M.A.Dağ A.Zeng?ngül A.?.Büyükbayram H.Özbağ D.2024-04-242024-04-2420010372-5480https://hdl.handle.net/11468/24483Epidermal growth factor (EGF) is a low molecular mass polypeptide with 53 amino acids and is known to stimulate cell proliferation and differentiation in a wide range of tissues. EGF is thought to have important functions in epithelial growth and differentiation and in wound healing. In the present study, the teratogenic effects of sialoadenectomy on rat gingival epithelia were investigated histologically. Twenty adult female Wistar albino rats were divided into two groups (N = 10), a control and an experimental group. The experimental group was subjected to sialoadenectomy in order to create EGF deficiency. After 60 days of sialoadenectomy (EGF deficiency), control group rats were killed using pentobarbital and their maxilla removed. The sections were stained with haematoxylineosin and Mason triple for evaluation by using a light microscope. Astatistically significant reduction in body mass was noted in rats in the experimental group when compared to the control group. Decreasing the thickness of keratization layer, irregularity and disappearance of microscopic papilla, intraepithelial focal cystic lesions resulting from EGF deficiency, and a decrease in saliva, were noted. As a result, epidermal growth factor deficiency performed by sialoadenectomy caused body mass reduction and gingival epithelia abnormalities.eninfo:eu-repo/semantics/closedAccessEpidermal Growth FactorGingival EpitheliaSialoadenectomyArticle71285962-s2.0-0035560393Q4