Doğru, Arzum GülerToprak, ÖmerÜner, Devrim Denizİzol, Bozan SerhatKaplan, İbrahimDoğru, Mehmetİpek, Fikret2022-05-272022-05-272020Doğru, A.G., Toprak, Ö., Üner, D.D., İzol, B.S., Kaplan, İ., Doğru, M. ve diğerleri. (2020). Comparison of the effect of periodontal therapy and diode decontamination and periodontal therapy alone on the amount of TNF-alpha in systemically healthy chronic periodontitis patients a non-randomized clinical trial. Analytical and Quantitave Cytopathology and Histopathology, 42(6), 180-188.0884-6812https://hdl.handle.net/11468/9912WOS:000619650600002Abstract OBJECTIVE: To evaluate the outcome of initial periodontal therapy and additional diode laser decontamination therapy on clinical parameters and the amount of tumor necrosis factor alpha (TNF-alpha) in gingival crevicular fluid (GCF) in patients with chronic periodontitis. STUDY DESIGN: The study included 22 patients who were diagnosed with chronic periodontitis and who had at least 1 (>= 5 mm) periodontal pocket in the posterior region of each upper left hemi-arcade. The study was designed as a split-mouth study involving mechanical therapy on the right side and nonsurgical periodontal therapy plus diode laser decontamination therapy on the left side. RESULTS: A statistically significant decrease was observed in clinical parameters at 3 months when compared to the values at baseline in both treatment areas. The change in clinical parameters at 3 months after therapy was not significantly different between the groups (p>0.05). The comparison of GCF TNF-alpha levels at baseline and at 3 months in the 2 treatment areas identified significant changes in the TNF-alpha levels in the hemi-arcade treated with laser diode contamination therapy, whereas the changes in the hemi-arcade treated with nonsurgical periodontal therapy were not significant (p>0.05). A between-group comparison revealed no statistically significant difference at 3 months post-therapy, while the difference at 1 month was found to be statistically significant. CONCLUSION: The study found that laser therapy in addition to nonsurgical periodontal therapy has a positive effect on the clinical parameters and proinflammatory TNF-alpha levels in the early period but makes no contribution in the long term.eninfo:eu-repo/semantics/closedAccessChronic periodontitisDental plaqueDental scalingDental surgeryDiode laserGingival crevicular fluidLasersNonsurgical periodontal therapyPeriodontal attachment lossPeriodontal diseasesPeriodontal pocketPeriodontitisTNF-alphaTumor necrosis factor alphaArticle426180188WoSIDEksikN/A