Demirbilek, HuseyinBacak, GokhanBaran, Riza TanerAvci, YahyaBaran, AhmetKeles, AysenurOzbek, Mehmet Nuri2024-04-242024-04-2420141308-57271308-5735https://doi.org/10.4274/jcrpe.1477https://hdl.handle.net/11468/19659Prepubertal unilateral gynecomastia is an extremely rare condition. At present, its etiology and management strategy are not well known. Two unrelated prepubertal boys of ages 8 and 9 who presented with complaints of unilateral enlargement of breast tissue are reported. Physical examination, biochemical, hormonal and oncologic work-up findings were normal. Both patients were treated with peripheral liposuction successfully. Histopathological and immunohistochemical examinations showed benign fibroglandular gynecomastia and intensive (3+) estrogen receptor expression in 100% of periductal epithelial cells. Although an extremely rare and generally benign condition, patients with prepubertal unilateral gynecomastia should have a full endocrine and oncologic work-up.eninfo:eu-repo/semantics/openAccessGynecomastiaPubertalPrepubertalUnilateralArticle64250253WOS:0003477857000092-s2.0-849165962512554189710.4274/jcrpe.1477Q2Q2