Taşkın, Irmak İçenGürbüz, Sevimİçen, Mehmet SaitDerin, Dilek CamFındık, Fatih Mehmet2023-11-012023-11-012023Taşkın, I. İ., Gürbüz, S., İçen, M. S., Derin, D. Ç. ve Fındık, M. F. (2023). Expression of sirtuin 2 and 7 in placenta accreta spectrum. Revista da Associacao Medica Brasileira , 69(8), 1-5.1806-9282https://www.scielo.br/j/ramb/a/4rhWT44C5YM43fTgM5BbHPz/?lang=enhttps://hdl.handle.net/11468/13015OBJECTIVE: This study aimed to investigate the expression levels of sirtuin 2 and sirtuin 7 in the placenta accreta spectrum to reveal their role in its pathogenesis. METHODS: A total of 30 placenta accreta spectrum, 20 placenta previa, and 30 controls were experienced. The sirtuin 2 and sirtuin 7 expression levels in the placentas of these groups were determined by Western blot. sirtuin 2 and sirtuin 7 serum levels in the maternal and fetal cord blood were examined by enzyme-linked immunosorbent assay. RESULTS: It was found that sirtuin 7 in placenta accreta spectrum was significantly lower in the placenta compared to the control and placenta previa groups (p[removed]0.05). CONCLUSION: Sirtuin 7 may play an important role in the formation of placenta accreta spectrum. The effect of decreased expression of sirtuin 7 might be tissue-dependent in the placenta accreta spectrum and needs to be investigated further.eninfo:eu-repo/semantics/openAccessEpithelial-mesenchymal transitionPlacenta accretaPlacenta previaSirtuin 2SirtuinsArticle69815WOS:0010515693000012-s2.0-851682515893758599510.1590/1806-9282.20230360Q2N/A