İçen, Mehmet SaitAgaçayak, ElifFındık, Fatih MehmetTunç, Senem YamanKaplan, İbrahimTan, İlhanEvsen, Mehmet SıddıkGül, Talip2021-09-272021-09-272020İçen, M.S., Ağaçayak, E., Fındık, F.M., Tunç, S.Y., Kaplan, İ., Tan, İ. ve diğerleri. (2020). Are serum Netrin-4 levels predictive of preeclampsia?. Ginekologia Polska, 91(12), 733-739.0017-00112543-6767https://journals.viamedica.pl/ginekologia_polska/article/view/66988https://hdl.handle.net/11468/7779WOS:000610981400003PMID: 33447992Objective: To investigate the levels of anti-angiogenic factors, namely sFlt-1 and Netrin-4, in patients with preeclampsia (PE). Material and methods: Cord-blood (UC) sFlt-1 and Netrin-4 concentrations were measured in 30 patients with severe PE, 30 patients with PE and 30 control infants and their mothers (MS). Results: Maternal sFlt-1 levels were significantly higher in the severe PE and PE groups than in the control group. There were no statistical differences among the three groups in maternal and fetal Netrin-4 levels. But Netrin-4 levels were found to be the lowest in the control group and higher in the PE and severe PE groups. The correlation analysis revealed a positive correlation between maternal sFlt-1 levels and maternal Netrin-4 levels (p = 0.012, and r = 0.263), maternal sFlt-1 levels and fetal sFlt-1 levels (p = 0.012, and r = 0.263). Conclusions: There was a positive correlation found between maternal sFlt-1 levels and maternal Netrin-4 levels. We are of the opinion that elevation in levels of Netrin-4 might be secondary to placental hypoxia occurring in PE. The present study led to the consideration of anti-angiogenic biomarkers (sFlt-1 and Netrin-4) on automated platforms for clinical use as an aid in establishing the diagnosis and prognosis of PE.eninfo:eu-repo/semantics/openAccesssFlt-1Netrin-4PreeclampsiaAnti-angiogenic effectsArticle9112733739WOS:0006109814000032-s2.0-850999995783344799210.5603/GP.a2020.0124Q3Q4