Bahceci, MTuzcu, AOgun, CCanoruc, NIltimur, KAslan, C2024-04-242024-04-2420050391-40971720-8386https://doi.org/10.1007/BF03345357https://hdl.handle.net/11468/14208Background and aims: C-reactive protein (CRP) is an inflammatory marker that predicts coronary heart disease (CHD) risk. Diabetes mellitus (DM) counts as a CHD risk equivalent. We aimed to compare serum high sensitivity CRIP (hs-CRP) levels in Type 2 diabetic (T2DM) men without CHD, non-diabetic CHD patients and T2DM patients with CHD. Subjects and methods: Four groups were formed; Group 1 [DM(+) CHD(-), no.=25], Group 2 [DM(-) CHD(+) no.=25], Group 3 [DM(+), CHD(+), no.=25], and Group 4 (controls, no.=30). Serum hs-CRP, insulin, glucose, total, HDL-, LDL- and VLDL-cholesterol, triglyceride levels and homeostasis model assessment for insulin resistance (HOMA-IR) index were determined. Results: Mean hs-CRP level of Group 1 (0.6 +/- 0.29) was not different statistically from Group 2 (1.44 +/- 0.97). Mean hs-CRP levels were higher in men with CHD, whether they were diabetic (Group 3; 3.83 +/- 2.01 mg/dl) or non-diabetic (Group 4), than in control subjects (0.16 +/- 0.15; p=0.0001 and p < 0.004, respectively). Mean hs-CRP level of Group 3 was also higher than Group 2 (p=0.0001). There was a positive correlation between serum hs-CRP and glycated hemoglobin (HbA(1c); r=0.277, p < 0.01), fasting insulin (r=0.336, p < 0.02) and HOMA-IR (r=0.348, p < 0.02) in T2DM men with or without CHD. Conclusions: T2DM men without CHD had similar CRP levels with non-diabetic CHD patients, whereas CRP levels of T2DM men with CHD were higher than non-diabetic men with CHD. Because of a positive correlation between serum hs-CRP and HbA(1c) fasting insulin and HOMA-IR, inflammation, insulin resistance and hyperglycemia jointly contribute to the cardiovascular risk in T2DM men. (c) 2005, Editrice Kurtis.eninfo:eu-repo/semantics/closedAccessType 2 DiabetesC-Reactive ProteinCoronary Heart DiseaseHoma-IrHba(1c)Article282145150WOS:0002287356000082-s2.0-204444653031588786010.1007/BF03345357Q1Q3