Aday, UlaşTatlı, FarukAkpulat, Faik V.İnan, MazlumKafadar, Mehmet TolgaBilge, HüseyinBaşol, ÖmerOǧuz, Abdullah2021-07-302021-07-302020Aday, U., Tatlı, F., Akpulat, F. V., İnan, M., Kafadar, M. T., Bilge, H. ve diğerleri. (2020). Prognostic significance of pretreatment serum lactate dehydrogenase-to-albumin ratio in gastric cancer. Wspolczesna Onkologia, 24(3), 145-149.1428-2526https://www.termedia.pl/Prognostic-significance-of-pretreatment-serum-lactate-dehydrogenase-to-albumin-ratio-in-gastric-cancer,3,42181,0,1.htmlhttps://hdl.handle.net/11468/7256WOS:000615631000001PMID: 33235539Aim of the study: To investigate the prognostic role of lactate dehydrogenase-to-albumin ratio (LAR) in gastric cancer patients undergoing curative resection. Material and methods: A retrospective study was conducted including resectable gastric cancer patients. According to the time-dependent receiver operating characteristics (ROC) analysis, the optimal threshold for pretreatment LAR was 5.5. The Kaplan-Meier method, Cox regression univariate and multivariate analyses were used to analyze the prognostic factors for disease-free survival and overall survival (OS). Results: The study cohort consisted of 81 patients, mean age was 60.2 ±13.8 (range, 29-87) years and 55 (67.9%) were male. The median OS time was 34.8 and 45 months in patients with LAR ≥ 5.5 (n = 50) and LAR < 5.5 (n = 31), respectively. Kaplan-Meier curves showed that with the increase in LAR there was reduced survival, but it was not statistically significant (p = 0.278). Multivariate analyses revealed that the positive lymph node ratio above 20% was an independent predictor in resectable gastric cancer patients (OR = 6.281, 95% CI: 1.135-34.767, p = 0.035). Conclusions: With the increase in LAR survival in gastric cancer decreased, but it was not statistically significant. Studies involving a large patient series are needed.eninfo:eu-repo/semantics/openAccessCurative surgeryGastric cancerLARSurvivalPrognostic significance of pretreatment serum lactate dehydrogenase-to-albumin ratio in gastric cancerPrognostic significance of pretreatment serum lactate dehydrogenase-to-albumin ratio in gastric cancerArticle243145149WOS:0006156310000012-s2.0-850958751813323553910.5114/wo.2020.100219Q2N/A