Can, CananKepenek, FeratKomek, HalilGundogan, CihanKaplan, IhsanTasdemir, BekirGuzel, Yunus2024-04-242024-04-2420220143-36361473-5628https://doi.org/10.1097/MNM.0000000000001607https://hdl.handle.net/11468/17319Aim In this study, we aimed to compare the diagnostic accuracy of F-18-fluorodeoxyglucose (F-18-FDG) and Gallium-68 labeled fibroblast activator protein inhibitor (Ga-68-FAPI)-04 PET/CT in the tumor-node-metastasis (TNM) staging of patients with nonsmall cell lung cancer (NSCLC) and investigate whether adenocarcinoma (ADC) and squamous cell cancer (SCC) exhibit different uptake patterns on Ga-68-FAPI-04 PET/CT. Materials and method Twenty-nine patients with a histopathologically-confirmed diagnosis of NSCLC, who had no history of previous radiation therapy or chemotherapy and underwent F-18-FDG PET/CT and Ga-68-FAPI-04 PET/CT imaging between January 2021 and December 2021 were included in this retrospective study. Staging was performed using the 8th edition of the TNM staging system on both F-18-FDG PET/CT and Ga-68-FAPI-04 PET/CT images. Standardized uptake value (SUV)(max) and tumor-to-background ratios (TBR) were calculated on primary lesions and metastases. Results There was no statistically significant difference in primary lesions in terms of SUVmax and TBR values. However, Ga-68-FAPI-04 PET/CT was significantly superior to F-18-FDG PET/CT in terms of the number of lymph nodes and bone metastases revealed. The SUVmax and TBR values of lymph nodes, hepatic lesions and bone lesions were significantly higher on Ga-68-FAPI-04 PET/CT than on F-18-FDG PET/CT. Ga-68-FAPI-04 PET/CT changed the disease stage of three patients (10.9%). The diagnostic accuracy of Ga-68-FAPI-04 PET/CT was 100%, whereas the diagnostic accuracy of F-18-FDG PET/CT was 89.6% (P = 0.250). Conclusion Although Ga-68-FAPI-04 PET/CT detected more lesions and higher diagnostic accuracy than F-18-FDG PET/CT in NSCLC, neither method was statistically superior to each other in terms of diagnostic accuracy in TNM staging.eninfo:eu-repo/semantics/closedAccessF-18- FdgGa-68-Fapi-04NsclcPetCtSuvmaxArticle431010841091WOS:0008534934000052-s2.0-851384482913597234010.1097/MNM.0000000000001607Q3Q4