Gokalp, DenizTuzcu, AlpaslanBahceci, MithatArikan, SenayPirinccioglu, Ayfer GozuBahceci, Selen2024-04-242024-04-2420090001-53851784-973Xhttps://doi.org/10.2143/AC.64.5.2042689https://hdl.handle.net/11468/18775Objective - Homozygous familial hypercholesterolemia (FH) is an extremely rare (1/1.000.000) condition characterized by markedly increased LDL cholesterol levels and a significantly increased risk of premature coronary heart disease (CHD). We aimed to evaluate the levels of high-sensitivity C-reactive protein (hs-CRP) and proinflammatory cytokines, which are known to be associated with atherogenesis, in patients with this condition. Method and results - A total of 10 patients with homozygous FH (5 women and 5 men, mean age 17.0 +/- 6.9 years, body mass index (BMI) (18.8 +/- 1.9 kg/m(2)) and 16 healthy controls were included. hs-CRP levels, proinflammatory cytokine levels and lipid parameters were measured and compared between patients and control subjects. Homozygous FH patients had significantly higher total cholesterol, LDL-cholesterol and Lp(a) levels and significantly lower triglycericle and HDL cholesterol levels, compared to controls (P = 0.0001, for all). Serum hs-CRP (3.7 +/- 1.3 mg/L vs. 0.6 +/- 0.6 mg/L) and IL-1 beta, IL-2R, IL-6, IL-8, IL- 10, TNF-alpha levels were all significantly higher in the homozygous FH group, compared to controls (P = 0.0001, for all). Conclusions - Homozygous FH patients have significantly higher levels of hs-CRP and circulating proinflammatory cytokines, which may explain their increased risk of atherosclerotic disease. hs-CRP is an important biomarker that may be helpful in the identification of asymptomatic CHD in FH patients.eninfo:eu-repo/semantics/closedAccessProinflammatory CytokinesHs-CrpHomozygous Familial HypercholesterolaemiaArticle645603609WOS:0002721837000052-s2.0-757490969892005850510.2143/AC.64.5.2042689Q3Q4