Maharani, Diah AyuRamadhani, AliaAdiatman, MelissaWimardhani, Yuniardini SeptoriniKusdhany, LindaRahardjo, AnyonYavuz, İzzet2024-04-242024-04-242017Maharani, D. A., Ramadhani, A., Adiatman, M., Wimardhani, Y. S., Kusdhany, L., Rahardjo, A. ve diğerleri. (2017). Efficacy of mouth rinse formulation based on cetylpyridinium chloride 0.1% in the control of dental calculus buildup. International Journal of Applied Pharmaceutics, 9, 176-180.0975-7058https://doi.org/10.22159/ijap.2017.v9s1.84_91https://hdl.handle.net/11468/23709Objective: This study aimed at comparing the antiplaque, anticalculus, and antigingivitis potentials of a mouth rinse containing essential oil, alcohol, zinc, and fluoride with a mouth rinse containing cetylpyridinium chloride (CPC) 0.1% over 1-, 2-, and 3-month periods. Methods: This study was a double-blind, parallel randomized clinical trial with a 3-day run-in phase. Respondents were asked to gargle twice daily with 15 ml of mouth rinse for 30 seconds after brushing teeth. Respondents were 80 females with a mean age of 21 years, and a single dental examiner was employed throughout the study to decrease the variance. Prophylaxis was performed for all respondents before the intervention. Three mouth rinses were tested: Group 1 with the mouth rinse containing CPC 0.1%, Group 2 as the negative control, and Group 3 as the positive control with a mouth rinse containing alcohol. Evaluations were conducted by plaque index, gingival index, calculus index, and CariScreen examinations. Results: The clinical trial showed that the mouth rinse with alcohol and the mouth rinse containing CPC 0.1% were effective in inhibiting bacterial buildup (antiplaque) and have anticalculus properties, but with no statistically significant antigingivitis effect. Conclusion: It was found that the mouth rinse containing alcohol has similar effectiveness with CPC 0.1% mouth rinse, but side effects, such as a burning sensation, were reported in the alcohol-containing mouth rinse. © 2017 The Authors. Published by Innovare Academic Sciences Pvt Ltd.eninfo:eu-repo/semantics/openAccessAnticalculusCetylpyridinium chlorideMouth rinseArticle91761802-s2.0-8503367683110.22159/ijap.2017.v9s1.84_91Q2