Kaplan, İbrahimSancaktar, EnverEce, AydınŞen, VelatTekkeşin, NilgünBaşaralı, Mustafa KemalKelekçi, SelviEvliyaoğlu, Osman2023-10-272023-10-272014Kaplan, İ., Sancaktar, E., Aydın, E., Şen, V., Tekkeşin, N., Başaralı, M. K. ve diğerleri. (2014). Gene polymorphisms of adducin GLY460TRP, ACE I/D, and AGT M235T in pediatric hypertension patients. Medical Science Monitor, 20, 1745-1750.1234-1010https://medscimonit.com/abstract/index/idArt/892140https://hdl.handle.net/11468/12986Background: Hypertension is a major global public health problem that affects both pediatric and adult populations. ACE I/D, AGT M235T, and ADD Gly460Trp polymorphisms are thought to be associated with primary hypertension. In the present study, we examined the frequency of these polymorphisms in a pediatric population with secondary hypertension. Material/Methods: Included in the study were 58 hypertensive and 58 normotensive pediatric patients. ACE I/D and AGT M235T polymorphisms are determined by conventional PCR; ADD Gly460Trp polymorphism was investigated using PCR amplification of genomic DNA. Results: There were significant differences between the control group and pediatric hypertensive group in terms of ACE I/D (P<0.05) and AGT M235T (P[removed]0.05) polymorphism. Conclusions: We suggest that RAS gene polymorphisms (ACE-I/D, AGT M235T) are significantly associated with susceptibility to diseases that lead to secondary hypertension.eninfo:eu-repo/semantics/openAccessGenesGeneticHypertensionPolymorphismRasArticle2017451750WOS:0003426479000012-s2.0-849081284582526217610.12659/MSM.892140Q1Q3