Azizoǧlu, MustafaArslan, SerkanÖzkorkmaz, Ebru GökalpAşır, FıratBasuguy, ErolOkur, Mehmet HanifiAydoğdu, BahattinKarabel, M. AlagözKaplan, İbrahim2024-03-112024-03-112023Azizoğlu, M., Arslan, S., Özkorkmaz, E. G., Aşır, F., Basuguy, E., Okur, H. ve diğerleri. (2023). Protective effects of Silymarin on testicular torsion/detorsion in rats. European Review for Medical and Pharmacological Sciences, 27(21), 10446-10453.2284-0729https://www.europeanreview.org/wp/wp-content/uploads/10446-10453.pdfhttps://hdl.handle.net/11468/13567OBJECTIVE: The present research aimed to study the possible protective effects of Silymarin on testicular I/R injury in a rat model evaluated through histopathology and biochemical parameters. MATERIALS AND METHODS: This research investigated the impact of Silymarin on IR damage in male Wistar albino rats. Animals were divided into three groups: group 1 (sham), group 2 (IR), and group 3 (IR+Silymarin). RESULTS: There were no notable differences in the levels of malondialdehyde (MDA), myeloperoxidase (MPO), and glutathione (GSH) across the three groups (p=0.260, p=0.486 and p=0.803, respectively). Contrarily, the total antioxidant status (TAS) levels exhibited significant variations between groups (p=0.001). The total oxidant status (TOS) levels also differed significantly between groups (p=0.004). The tissue evaluations uncovered substantial differences in the Johnson score, which is used to gauge testicular damage. A distinct contrast was seen between Group 1 and Group 2, and also between Group 2 and Group 3, with an all-encompassing p-value lower than 0.01. The same significant disparities were found for the percentages of Bax and Annexin V immunostaining (p<0.01 for each), reflecting the inflammation and apoptosis brought about by ischemia-reperfusion and the protective effects of the treatment. CONCLUSIONS: The outcomes of the current investigation showed that Silymarin could be a valuable agent for reducing testicular tissue damage following I/R injury.eninfo:eu-repo/semantics/closedAccessSilymarinIschemia-reperfusionTesticular torsionTesticular damageSpermatogenesisArticle27211044610453WOS:0011106242000032-s2.0-851775027573797536810.26355/eurrev_202311_34319Q2N/A