Yokus, BCakir, DUAkdag, MZSert, CMete, N2024-04-242024-04-2420051071-5762https://doi.org/10.1080/10715760500043603https://hdl.handle.net/11468/16902Extremely low frequency (ELF) electromagnetic field (EMF) is thought to prolong the life of free radicals and can act as a promoter or co-promoter of cancer. 8-hydroxy-2-deoxyguanosine (8OHdG) is one of the predominant forms of radical-induced lesions to DNA and is a potential tool to asses the cancer risk. We examined the effects of extremely low frequency electro magnetic field (ELF-EMF) (50 Hz, 0.97 mT) on 8OHdG levels in DNA and thiobarbituric acid reactive substances (TBARS) in plasma. To examine the possible time-dependent changes resulting from magnetic field, 8OHdG and TBARS were quantitated at 5 0 and 100 days. Our results showed that the exposure to ELF-EMF induced oxidative DNA damage and lipid peroxidation (LPO). The 8OHdG levels of exposed group (4.39 +/- 0.88 and 5.29 +/- 1.16 8OHdG/dG. 105, respectively) were significantly higher than sham group at 50 and 100 days (3.02 +/- 0.63 and 3.46 +/- 0.38 8OHdG/dG.10(5)) (p < 0.001, p < 0.001). The higher TBARS levels were also detected in the exposure group both on 50 and 100 days (p < 0.001, p < 0.001). In addition, the extent of DNA damage and LPO would depend on the exposure time (p < 0.05 and p < 0.05). Our data may have important implications for the long-term exposure to ELF-EMF which may cause oxidative DNA damage.eninfo:eu-repo/semantics/closedAccessDna DamageMagnetic Field8-Hydroxy-2 '-Deoxyguanosine8-OxoguanineThiobarbituric AcidTbarsArticle393317323WOS:0002281313000102-s2.0-159444163951578823610.1080/10715760500043603Q2Q3