Ucmak, DeryaAbakay, Ozlem2024-04-242024-04-2420200393-63842283-9720https://doi.org/10.19193/0393-6384_2020_4_357https://hdl.handle.net/11468/18757Introduction: Psoriasis is a chronic systemic inflammatory disease. Obstructive sleep apnea syndrome (OSAS) is a disorder that is characterized by obstructive apneas and hvpopneas due to repetitive collapse of the upper airway during sleep. Psoriasis and OSAS are associated with chronic inflammation and an abnormal immune response. We aimed to compare the prevalence of OSAS in psoriatic patients to healthy controls and determine whether certain clinical and laboratory parameters may be associated with OSAS in psoriatic patients. Material and Methods: A total of 30 patients who were diagnosed with psoriasis and 30 healthy controls were included in this prospective study. All participants were evaluated with nocturnal polysomnography. Data on demographic information, laboratory findings, anthmpometric measurements, Epworth Sleepiness Scale (ESS) score, Dermatology Life Quality Index (DLQI) score, Psoriasis Area and Severity Index (PASI) score were recorded. Results: The mean age of the patients was 36.8 +/- 12.6 years; and the mean age of the control group was 39.9 +/- 11.2 years. OSAS was diagnosed in nine (30%) of the psoriasis patients and two (6.7%) of the healthy controls (p=0.02). AHI (5.1 +/- 5.4 vs. 2.3 +/- 2.6, p=0.015), ESS scores (4.7 +/- 3.7 vs. 2.8 +/- 2.1, p=0.022), serum CRP levels (5.1 +/- 3.2 vs. 1.4 +/- 0.9 mg/dl, p<0.001) were higher in the psoriatic patients, compared to the control group, whereas HDL-cholesterol levels (37.6 +/- 8.6 vs. 44.9 +/- 10.8 mg/dl, p=0.005) showed the opposite. Psoriatic patients with OSAS had higher DLQI scores (p=0.001), PASI (p=0.042), Apnea-Hypopnea Index (AHI) (p<0.001 ), ESS scores (p<0.001 ) and serum CRP values (p<0.001) compared to those without OSAS. Eight patients with OSAS (88.9%) had nail involvement (p=0.020) compared to one patient (11.1%) without OSAS. Conclusions: Increased PASI and DLQI scores, CRP levels were observed in psoriatic patients and OSAS was increased in those with nail involvement. The early evaluation of psoriatic patients for the presence of OSAS may be useful in prevention of comorbidities.eninfo:eu-repo/semantics/closedAccessPsoriasisObstructive Sleep Apnea SyndromeComorbidityInflammationArticle36422932298WOS:0005528979000202-s2.0-8509053502810.19193/0393-6384_2020_4_357N/AQ4