Meric, NerminAydemir, Murat2024-04-242024-04-2420160022-328X1872-8561https://doi.org/10.1016/j.jorganchem.2016.06.002https://hdl.handle.net/11468/15726The asymmetric reduction of prochiral ketones is a pivotal reaction for the preparation of chiral alcohols which form an extremely important class of intermediates for fine chemicals and pharmaceuticals. Especially, iridium-based asymmetric reduction of ketones to enantiomerically enriched alcohols has recently attracted important attention by a number of research groups and interest in this area is growing. Therefore, a series of novel neutral mononuclear iridium(III) ferrocenyl-phosphinite complexes have been prepared and applied in the iridium(III)-catalyzed asymmetric transfer hydrogenation (ATH) of ketones to give corresponding secondary alcohols with outstanding enantioselectivities and reactivities using 2-propanol as the hydrogen source (up to 99% ee and 99% conversion). It was seen that the substituents on the backbone of the ligands resulted in a significant effect on both the activity and % enantioselectivity. Furthermore, the structural elucidation of the complexes was carried out by elemental analysis, IR and multi-nuclear NMR spectroscopic data. (C) 2016 Elsevier B.V. All rights reserved.eninfo:eu-repo/semantics/closedAccessIridium(Iii)Monodendate Ferrocenyl-PhosphiniteHomogeneous CatalysisAsymmetric Transfer HydrogenationKetonesArticle819120128WOS:0003821990000162-s2.0-8497727784510.1016/j.jorganchem.2016.06.002Q2Q2