Bozkurt, MehtapDag, EvinOktayoglu, PelinEm, SerdaYuksel, HaticeCaglayan, MehmetSariyildiz, Mustafa Akif2024-04-242024-04-2420140393-63842283-9720https://hdl.handle.net/11468/22021Objective: To assess serum prolidase enzyme activity and oxidative stress in patients with scleroderma (also known as systemic sclerosis, or SSc) and determine its relationship with serum oxidative status. Methods: The study population consisted of SSc patients (n = 21) and healthy participants (n =29). Serum prolidase enzyme activity, total antioxidant status (TAS), total oxidative status (TOS), oxidative stress index (051), and paraoxonase-1 (PON-1) levels were compared betweeen the two groups. Results: The mean duration of SSc involvement was 5 years; and the mean modified Rodnan skin score was 16. No statistically significant differences existed between the SSc groups and the control participants in terms of age, gender, TAS, PON-I, and haematocrit levels. Serum prolidase activity, 051, and TOS levels were statistically significantly higher in SSc patients in comparison with controls participants. Also serum prolidase activity was statistically higher in Raynaud's phenomenon positive patients than Raynaud's phenomenon negative patients. But no correlation emerged between the serum prolidase activity and modified Rodnan Skin Score (P=0.235, r=0.304). Conclusion: High prolidase activity may indicate critical biological activities relevant to pathological events in SSc, and this activity may be a biological indicator of disease. Further studies are needed to verify these findings.eninfo:eu-repo/semantics/closedAccessBone Marrow Mesenchymal Stem CellsMouseCultureArticle301127132WOS:000335937700020Q4