Karadayi B.Zincircioğlu S.B.Dirier A.2024-04-242024-04-2420061306-133Xhttps://hdl.handle.net/11468/24268Cancer of the rectum is a frequent malign disease of both sexes and its primary treatment is surgery. Postoperative chemotherapy is the generally preferred adjuvant treatment modality but its results are not still satisfactory. Recent studies have reported that total mesorectal excision technique with preoperative chemoradiotherapy is superior to postoperative adjuvant treatment in terms of local disease control. The question of timing of the adjuvant treatments like radiotherapy, chemotherapy and chemoradiotherapy will be discussed in light of the randomized clinical trials with sufficient patient number. In conclusion, current recommendation is preoperative concomitant chemotherapy plus radiotherapy.trinfo:eu-repo/semantics/closedAccessAntineoplastic Combined Chemotherapy ProtocolsNeoadjuvant TherapyRectal NeoplasmArticle16147532-s2.0-33646445796N/A