Kaplan, IbrahimBulut, MahmutAtli, AbdullahGunes, MehmetKaya, Mehmet CemalColpan, Leyla2024-04-242024-04-2420151601-5215https://doi.org/10.1017/neu.2015.5https://hdl.handle.net/11468/16374Objective Carcinoembryonic antigen (CEA) is an oncofetal glycoprotein that is widely used as a tumour marker in adenocarcinomas. However, several non-neoplastic conditions, including acute and chronic inflammation and other inflammation-related conditions, are characterised by increased CEA concentrations. Bipolar disorder (BD) ranks seventh among the worldwide burden of non-fatal diseases. Inflammatory biomarkers have been considered as one of the main key pillars of a multifactorial approach for prediction of BD in an at-risk population. BP is accompanied by activation of inflammatory, cell-mediated and negative immunoregulatory cytokines. Methods We measured the levels of CEA in serum samples from 44 individuals with euthymic BP out-patients and 45 healthy controls. Patients were diagnosed according to the DSM-IV criteria. CEA was measured by an electrochemiluminescence immunoassay. Results The mean serum CEA concentration was 2.361.52 and 1.77 +/- 0.98 mu g/l in patients and controls, respectively. CEA levels were significantly increased in euthymic BP patients when compared with controls (p=0.031). Conclusions This study suggests that CEA is increased in BD and supports a role for immune activation in the core pathological mechanisms of BP. CEA levels may be a secondary marker for diagnosing BP.eninfo:eu-repo/semantics/closedAccessBipolar DisorderCeaProinflammatory CytokinesArticle273177181WOS:0003543916000062-s2.0-849292843292569717510.1017/neu.2015.5Q1Q4