Kemaloglu, SOzkan, UYilmaz, FNas, KGur, AAcemoglu, HKarasu, H2024-04-242024-04-2420031362-4393https://doi.org/10.1038/sj.sc.3101466https://hdl.handle.net/11468/16459Study design: A randomized-controlled experimental study was conducted to investigate the effectiveness of recombinant tissue plasminogen activator (rt-PA) on postlaminectomy epidural fibrosis in rats. Setting: Diyarbakir, Turkey. Methods: In a rat model, allowing objective histopathological quantification, the postoperative epidural scar formation was investigated and the potential of local rt-PA in preventing the production of epidural fibrosis was assessed. Rats were randomly allocated to local rt-PA (12 rats) or control (12 rats). Results: Findings suggest a beneficial effect of rt-PA in decreasing the epidural. fibrosis following laminectomy when compared with control groups for all investigated parameters such as intermuscular scar (P = 0.04), middle scar (P = 0.001), deep scar (P = 0.001) and dural adhesion (P = 0.01) except new bone formation. The presence of arachnoiditis was less in treatment group (P = 0.01). Conclusion: In rats, the topical thrombolysis with rt-PA is safe and efficacious in preventing postlaminectomy epidural. fibrosis. This Thrombolytic therapy with rt-PA after spine surgery may come to play an important role in the prevention of epidural fibrosis and arachnoiditis.eninfo:eu-repo/semantics/openAccessSpinal Epidural FibrosisLaminectomyRt-PaArticle418427431WOS:0001847968000022-s2.0-00415890761288353910.1038/sj.sc.3101466Q1Q3