Atalay, YusufGunes, NedimGuner, Mehmet DervisAkpolat, VeysiCelik, Mustafa SalihGuner, Rezzan2024-04-242024-04-2420151177-8881https://doi.org/10.2147/DDDT.S89669https://hdl.handle.net/11468/18788Background: The aim of this study was to evaluate the effects of a phosphodiesterase inhibitor pentoxifylline (PTX), electromagnetic fields (EMFs), and a mixture of both materials on bone fracture healing in a rat model. Materials and methods: Eighty male Wistar rats were randomly divided into four groups: Group A, femur fracture model with no treatment; Group B, femur fracture model treated with PTX 50 mg/kg/day intraperitoneal injection; Group C, femur fracture model treated with EMF 1.5 +/- 0.2 Mt/50 Hz/6 hours/day; and Group D, femur fracture model treated with PTX 50 mg/kg/day intraperitoneal injection and EMF 1.5 +/- 0.2 Mt/50 Hz/6 hours/day. Results: Bone fracture healing was significantly better in Group B and Group C compared to Group A (P<0.05), but Group D did not show better bone fracture healing than Group A (P>0.05). Conclusion: It can be concluded that both a specific EMF and PTX had a positive effect on bone fracture healing but when used in combination, may not be beneficial.eninfo:eu-repo/semantics/openAccessBonesElectromagnetic FieldsFracture HealingPhosphodiesterase InhibitorPentoxifyllineRatsArticle951955201WOS:0003610155000022-s2.0-849412541172638868710.2147/DDDT.S89669Q1Q2