Synthesis of chiral diaza 18-crown-6 ethers from chiral amines and molecular recognition of potassium and sodium salts of amino acids

Demirel, NBulut, Y2024-04-242024-04-2420030957-4166https://doi.org/10.1016/S0957-4166(03)00594-9https://hdl.handle.net/11468/16334A practical synthesis of chiral amine precursors 3 and 4 and chiral diaza 18-crown-6 ethers 5. 6 and 7 starting from chiral amines are reported. The molecular recognition of these chiral crown ethers for amino acids potassium and sodium salts has been characterized by UV-vis. The selectivity order is Phe>Thr>Ala. In the case of 6 the cavity of the macrocycle plays ail important role in recognition. (C) 2003 Elsevier Ltd. All rights reserved.eninfo:eu-repo/semantics/closedAccess[No Keyword]Synthesis of chiral diaza 18-crown-6 ethers from chiral amines and molecular recognition of potassium and sodium salts of amino acidsSynthesis of chiral diaza 18-crown-6 ethers from chiral amines and molecular recognition of potassium and sodium salts of amino acidsArticle141726332637WOS:0001853112000222-s2.0-004188656910.1016/S0957-4166(03)00594-9N/AQ2