Çakır, ÖmerAyyıldız, OrhanGöz, MustafaŞit, DedeEren, Nesimi2024-04-242024-04-242007Çakır, Ö., Ayyıldız, O., Göz, M., Şit, D. ve Eren, N. (2007). Myocardial infarction and venous thrombosis in a 42-year old woman with heterozygous methylenetetrahydrofolate reductase (MTHRF) gene mutation, hyperhomocysteinemia, and protein C deficiency. International Journal of Cardiology, 117(3), e98-e100.0167-5273https://doi.org/10.1016/j.ijcard.2006.11.204https://hdl.handle.net/11468/23313https://www.sciencedirect.com/science/article/pii/S0167527307002288?via%3DihubObjective: Hyperhomocysteinemia and protein C deficiency have synergistic effect on the onset of thrombotic disease. Methods: We report a 42-year old woman with myocardial infarction and venous thrombosis in whom recognition of heterozygous MTHRF gene mutation, hyperhomocysteinemia, and protein C deficiency. Results: The patient was treated successfully with coronary artery bypass graft surgery and systemic anticoagulation. Conclusions: Our report emphasize that a combined hyperhomocysteinemia, and protein C deficiency may be a high risk factor for arterial and venous thromboembolic events in young adults. These patients might be candidates for indefinite anticoagulation.eninfo:eu-repo/semantics/closedAccessHyperhomocysteinemiaMthrf gene mutationProtein C deficiencyArticle1173e98e1002-s2.0-339477163651736005910.1016/j.ijcard.2006.11.204Q1