Synthesis of novel chiral Schiff-base ligands and their application in asymmetric nitro aldol (Henry) reaction

Colak, MehmetAral, TarikHosgoeren, HalilDemirel, Nadir2024-04-242024-04-2420070957-4166https://doi.org/10.1016/j.tetasy.2007.04.025https://hdl.handle.net/11468/16100Chiral Schiff-bases prepared from chiral amino alcohols catalyze the enantio selective Henry (nitro aldol) reaction between nitromethane and p-nitrobenzaldehyde in the presence of Cu(OTf)(2) and Zn(OTf)(2). Zn(OTf)(2) promoted the reaction yield, while Cu(OTf)(2) promoted the enantiomeric excess. The highest enantioselectivities were observed with ligand 3 (44% ee) and ligand 5 (47% ee). (C) 2007 Elsevier Ltd. All rights reserved.eninfo:eu-repo/semantics/closedAccess[No Keyword]Synthesis of novel chiral Schiff-base ligands and their application in asymmetric nitro aldol (Henry) reactionSynthesis of novel chiral Schiff-base ligands and their application in asymmetric nitro aldol (Henry) reactionArticle18911291133WOS:0002478980000152-s2.0-3424989499810.1016/j.tetasy.2007.04.025N/AQ1