Ucak, HaydarDemir, BetulCicek, DemetDertlioglu, Selma BakarAkkurt, Zeynep MeltemUcmak, DeryaHalisdemir, Nurhan2024-04-242024-04-2420130954-66341471-1753https://doi.org/10.3109/09546634.2013.800181https://hdl.handle.net/11468/19092Background: Pruritus ani (PA) is defined as intense chronic itching affecting perianal skin. Objective: We aimed to determine the efficacy of topical tacrolimus treatment in atopic dermatitis (AD) patients who have PA. Methods: The study included 32 patients with AD who were suffering PA. Patients were randomized into two groups. In total, 16 patients used 0.03% tacrolimus ointment and 16 patients used vaseline as placebo. All groups applied topical treatments to their perianal area twice daily for 4 weeks. The treatments were then reversed for 4 weeks after a 2 weeks wash out period. Results: In total, 32 patients with AD who had refractory anal itching were enrolled in this study. None of the patients had obtained successful results with previous treatments. There was a statistically significant decrease in the recorded EASI, DLQI and itching scores for the tacrolimus group compared to the placebo group at weeks 4 and 6 of treatment (p < 0.05). Conclusion: Topical tacrolimus treatment was well tolerated and effective in controlling persistent PA in AD patients.eninfo:eu-repo/semantics/closedAccessAnal ItchingDermatology Life Quality IndexEczema Area And Severity IndexAtopic DermatitisPruritus AniTacrolimus OintmentArticle246454457WOS:0003272579000132-s2.0-848878601472363899710.3109/09546634.2013.800181Q1Q2