Bodur, HaticeYurdakul, Fatma GulDuruoz, Mehmet TuncayCay, Hasan FatihUcar, UlkuKeskin, YasarSargin, Betul2024-04-242024-04-2420212148-50461309-0283https://doi.org/10.46497/ArchRheumatol.2021.8215https://search.trdizin.gov.tr/yayin/detay/445721https://hdl.handle.net/11468/19804Objectives: This study aims to evaluate the effectivity of Familial Mediterranean Fever Quality of Life (FMF-QoL) Scale for the measurement of QoL in patients with FMF and to perform correlations between related clinical variables in Turkish patients. Patients and methods: This multicenter prospective study performed between December 2017 and November 2018 included 974 FMF patients (334 males, 640 females; median age: 35; range, 26 to 45 years). Sociodemographic characteristics and clinical features were recorded. All participants were asked to complete the FMF-QoL Scale, Short Form-36 (SF-36), Hospital Anxiety and Depression Scale (HADS), Health Assessment Questionnaire (HAQ), and Functional Assessment of Chronic Illness Therapy (FACIT) Scale. Results: The median FMF-QoL Scale score was 26. Higher FMF-QoL Scale scores were shown to be related to female sex, illiteracy or primary education, monthly low-income (US$<300), smoking, late-onset FMF (>20 years), a higher number of attacks per month (>1/month), and severe disease. FMF-QoL Scale scores were correlated negatively with subscales of SF-36, and positively with HADS-anxiety and HADS-depression scores, HAQ and FACIT. Conclusion: Female sex, smoking, lower educational status, more severe disease, fatigue, and functional impairment were associated with poor QoL. FMF-QoL Scale was noted as a valid and simple patient-reported outcome instrument and correlated with the SF-36 scale.eninfo:eu-repo/semantics/openAccessAutoinflammatory DiseasesDepressionFatigueHereditaryLife QualityArticle362159166WOS:0006575137000014457213452791910.46497/ArchRheumatol.2021.8215Q4