Çorum, OrhanÇorum, Duygu DurnaAltan, FerayEr, AyşeÇetin, GülÜney, Kamil2021-09-142021-09-142019Çorum, O., Çorum, D. D., Altan, F., Er, A., Çetin, G., Üney, K. ve diğerleri. (2019). Pharmacokinetics of intravenous and intramuscular danofloxacin in red-eared slider turtles (Trachemys scripta elegans). Journal of Veterinary Medical Science, 81(5), 753-757.0916-7250https://www.jstage.jst.go.jp/article/jvms/81/5/81_18-0609/_articlehttps://hdl.handle.net/11468/7582PMID:30853667This study aimed to investigate the pharmacokinetics of danofloxacin in red-eared slider turtle (Trachemys scripta elegans) following a single intravenous (IV) and intramuscular (IM) administrations of 6 mg/kg, using a two-way crossover study with 30-day washout period. Eight clinically healthy red-eared slider turtle weighing 410-600 g (mean 490 g) were used for the study. Danofloxacin concentrations were measured using the reversed-phase high-performance liquid chromatography. The plasma concentration-time data were evaluated by a non-compartmental method. After IV administration, the elimination half-life (t1/2 ʎ z), mean residence time (MRT0-∞), area under the concentration-time curve (AUC0-∞), volume of distribution at steady state and total body clearance in plasma were 24.17 hr, 30.64 hr, 143.31 hr·μg/ml, 1.29 l/kg and 0.04 l/hr/kg, respectively. Following IM administration, t1/2ʎz, MRT0-∞AUC0-∞,peak concentration (Cmax), time to reach Cmax, and bioavailability in plasma were 32.00 hr, 41.15 hr, 198.23 hr·μg/ml, 8.75 μg/ml, 1.5 hr and 139.89%, respectively. Danofloxacin has clinically superior pharmacokinetic properties, including the complete IM absorption, slow elimination and wide volume of distribution in redeared slider turtles. However, further pharmacokinetics/pharmacodynamics studies are necessary for the treatment of diseases caused by susceptible bacteria with known minimum inhibitory concentration values in red-eared slider turtles.eninfo:eu-repo/semantics/openAccessBioavailabilityDanofloxacinPharmacokineticsRed-eared slider turtlesPharmacokinetics of intravenous and intramuscular danofloxacin in red-eared slider turtles (Trachemys scripta elegans)Pharmacokinetics of intravenous and intramuscular danofloxacin in red-eared slider turtles (Trachemys scripta elegans)Article815753757WOS:0004720059000212-s2.0-850670990753085366710.1292/jvms.18-0609Q2Q3