Öztürk, HayrettinAldemir, MustafaBüyükbayram, HüseyinDokucu, Ali İhsanOtçu, Selçuk2024-04-242024-04-242001Öztürk, H., Aldemir, M., Büyükbayram, H., Dokucu, A. İ. ve Otçu, S. (2001). The effects of the nitric oxide donor molsidomine prevent in warm ischemia-reperfusion injury of the rat renal - A functional and histopathological study. International Urology and Nephrology, 32(1), 604-607.0301-1623https://doi.org/10.1023/A:1014465509773https://hdl.handle.net/11468/23371https://link.springer.com/article/10.1023/A:1014465509773Aim of this experimental study is to verify the protective effect of molsidomine on the renal function and structural modifications in the ischemia-reperfusion rat kidney. Sixty-eight male Sprague-Dawley rats, which were right nephrectomized and occluded left renal artery for 60 minutes were used. Group I (n = 10) sham-operated animals, which only underwent right nephrectomy. Group II (n = 20) Untreated ischemic rats, which underwent left renal ischemia by occlusion of the renal artery for 60 minutes before blood was restored. Group III (n = 18) molsidomine treated ischemic rats, Group IV (n = 20) L-NAME (NG-nitro-L-arginine methyl ester) treated ischemic rats. Serum creatinine and blood urea nitrogen (BUN) were measured daily and biopsies were obtained from the remaining left kidneys. At seventh day, 55% and 50% of the rats remained alive at the G-II and G-IV respectively. Molsidomine treated rats (G-III) were alive and healthy at day 7. The serum creatinine and BUN levels were significantly higher in G-II and G-IV when compared with the sham-operated group (G-I). G-III rats showed a rapid return to the normal serum creatinine and BUN values on postoperative days 1, 2, 3 and 4. The obtained values in G-III were significantly lower in comparison to the values of G-II and G-IV. The most severe damage (grade 3 to 4) was determined in the kidneys of rats from GII or GIV. The degree of renal tubular damage in GIII was evaluated as grade 1 or 2 tubular damage according to Jablonkski's scale. Our findings suggested that the administration of molsidomine may vanquish the pernicious effects of warm ischemia on kidney structure and function.eninfo:eu-repo/semantics/closedAccessMolsidomineNg-Monomethyl-L-ArginineRenal warm ischemia and reperfusion injuryArticle3246016072-s2.0-00357267951198954910.1023/A:1014465509773Q2