Turhanoğlu S.Özyilmaz M.A.Tok D.Ölmez G.Ş Çinar F.Bayhan N.2024-04-242024-04-2419991124-8882https://hdl.handle.net/11468/24509The aim of this study was to compare the efficacy and safety of ondansetron plus dimenhydrinate with ondansetron or dimenhydrinate alone and control groups in prevention of postoperative nausea and vomiting (PONV). We studied 100 ASA I-II females undergoing general anaesthesia for major gynaecological surgery. Patients were allocated randomly to one of four groups and administered ondansetron 4 mg i.v. to groups I and II immediately prior to the induction of anaesthesia and dimenhydrinate 50 mg i.m. to groups II and III about 30 minutes before operation. The patients of group IV were administered 0.9% saline as placebo and were accepted as a control group. A standardized anaesthetic tecnique and postoperative analgesia were used in all patients. The incidence of nausea in the ondasetron with dimenhydrinate group was lower than in the other groups (p < 0.05). The incidence of vomiting in the ondansetron with dimenhydrinate group was significantly lower at the first six hours of the postoperative period than in the control group (p < 0.05). Sedation was significantly greater with dimenhydrinate groups for the first hour of the postoperative period (p < 0.05). We conclude that prophylactic administration of combined ondansetron and dimenhydrinate is more effective in preventing PONV than ondansetron or dimenhydrinate alone and control groups in women undergoing major gynaecological surgery.eninfo:eu-repo/semantics/closedAccessDimenhydrinateGynaecologicalNauseaOndansetronSurgeryVomitingArticle5031931992-s2.0-0033499063N/A