Akdeniz, CananDoğru, Arzum Güler2025-02-052025-02-052024Akdeniz, C. ve Doğru, A. G. (2024). The use of gingival crevicular fluid as a potential biomarker for periodontal disease. Dicle Dental Journal, 25(1), 19-24.2822-6755https://dergipark.org.tr/en/pub/dicledentj/issue/83876/1434777https://hdl.handle.net/11468/29432Gingival crevicular fluid (GCF) is an extremely valuable research material in the detection of periodontal diseases. The study of GCF components contributes to clinical diagnosis and helps us understand the mechanism of periodontal diseases. GCF is important for non-invasive analysis of periodontitis as it shows markers of connective tissue and bone destruction. GCF can be used in the future as a diagnostic tool for the identification of periodontitis, but it can also help in the detection of periodontitis progression. Early detection of periodontitis progression provides clinical benefit by allowing better control of disease activity and may improve patient follow-up. The aim of this review is to investigate the various enzymes and biomediators released in the GCF in periodontal disease and to provide an update on their role in inflammation.eninfo:eu-repo/semantics/openAccessPeriodontitisBiomarkerGingival crevicular fluidHost-derived enzymeGCFArticle2511924