Kararmaz, AKaya, STurhanoglu, SOzyilmaz, MA2024-04-242024-04-2420030001-51721399-6576https://doi.org/10.1034/j.1399-6576.2003.00052.xhttps://hdl.handle.net/11468/16427Background: The purpose of this prospective study was to determine the effects of high-dose propofol on the incidence of fasciculations and myalgia, and to evaluate changes in creatine kinase levels following the administration of succinylcholine in 90 women who underwent laparoscopy. Methods: Patients were randomly assigned to one of three groups. Induction of anesthesia was performed with thiopentone 5 mg kg(-1) in Group I (n = 30), propofol 2 mg kg(-1) in Group II (n = 30), and propofol 3.5 mg kg(-1) in Group III (n = 30). Then succinylcholine 1 mg kg(-1) was administered to the patients for intubation. Results: Fasciculation was absent in 20% of Group III patients, and no vigorous fasciculation occurred in this group. Furthermore, the severity of fasciculation in Group III was significantly lower than in the other two groups (P = 0.01). Seventy per cent of patients had no myalgia in Group III, 39.2% in Group II and 37% in Group I (P = 0.007). Severity of myalgia was also significantly lower in Group III compared with the other two groups (P = 0.011). Post-operative creatine kinase levels were significantly higher than their baseline values in Groups I and II (P < 0.0001). Conclusion: Administration of propofol 3.5 mg kg(-1) is effective in reducing fasciculations and myalgia after succinylcholine.eninfo:eu-repo/semantics/closedAccessAnestheticsPropofolComplicationsFasciculationsMyalgiaNeuromuscular RelaxantsSuxamethoniumArticle472180184WOS:0001813982000092-s2.0-00372999091263104710.1034/j.1399-6576.2003.00052.xQ2Q2