Yilmaz, BulentKoklu, SeyfettinBuyukbayram, HuseyinYalcin, KendalKorkmaz, UgurPosul, EmrahCan, Guray2024-04-242024-04-2420151680-69051729-0503https://doi.org/10.4314/ahs.v15i3.3https://hdl.handle.net/11468/19740Background: The effect of hepatitis B virus (HBV) infection on fatty liver disease is unclear.. Objectives: The aim of this study was to investigate the viral and host causes of fatty liver in chronic hepatitis B (CHB) patients. This study included 88 CHB patients of which 17 were not treated. Liver biopsy was performed in each patient. Group 1 included those with hepatic steatosis (n=28) and group 2 those without hepatic steatosis. The groups were compared in terms of age, body mass index (BMI), Homeostasis Model Assessment-Insulin Resistance (HOMA-IR), viral load, biochemical parameters and histological findings. Patients in group 1 were subdivided according to the degree of steatosis as follows: grade 1 (15 patients, 53.6%), grade 2 (6 patients, 21.4%), and grade 3 (7 patients, 25%). Results: In group 1 (n=28), mean age, BMI, cholesterol, and HOMA-IR were found to be significantly higher than in group 2 (n=60). There were no significant differences in the positivity of viral load, HbeAg, treatment, fibrosis and other laboratory parameters between the two groups. HOMA-IR was the only independent predictive factor of liver steatosis in patients with CHB in logistic regression analysis. Conclusion: Hepatic steatosis in CHB patients was associated with host metabolic factors.eninfo:eu-repo/semantics/openAccessChronic Hepatitis BLiver SteatosisHoma-IrBmiBiopsyArticle153714718WOS:0003648190000022-s2.0-849413313202695795710.4314/ahs.v15i3.3Q2Q3