Güneş, AliEce, AydınAktar, FesihTan, İlhanSöker, MuratKarabel, DuranBalık, HasanUluca, ÜnalŞen, VelatYolbaş, İlyas2024-04-242024-04-242015Güneş, A., Ece, A., Aktar, F., Tan, İ., Söker, M., Karabel, D. ve diğerleri. (2015). Urinary kidney injury molecules in children with iron-deficiency anemia. Medical Science Monitor, 21, 4023-4029.1234-1010https://doi.org/10.12659/MSM.896794https://hdl.handle.net/11468/23594Background: The aim of this study was to investigate the urine levels of human kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), N-acetyl-?-D-glucosaminidase (NAG), and liver-type fatty acid-binding protein (L-FABP) in children with iron-deficiency anemia (IDA). Material/Methods: Thirty-five children with IDA and 32 matched healthy controls were recruited. We assessed complete blood count, serum iron, iron-binding capacity, ferritin, serum levels of urea, creatinine (Cr), sodium (Na), potassium (K), calcium (Ca), and glucose levels. Estimated glomerular filtration rate (eGFR) was calculated. Urinary NAG, NGAL, KIM-1, and L-FABP were measured and divided by urine creatinine for comparisons. Results: There were no significant differences in serum urea, Cr, or eGFR between the IDA group and the control group (p> 0.05, for all). IDA patients had significantly higher urine NGAL/Cr, L-FABP/Cr, KIM-1/Cr, and NAG/Cr compared with the control group (p<0.05). There were significant negative correlations between hemoglobin, hematocrit, red blood cell count, and urine NGAL/Cr, NAG/Cr, L-FABP/Cr, KIM-1/Cr levels (p<0.05). Conclusions: Higher urinary kidney injury molecule levels in IDA patients suggest a possible subclinical renal injury in pediatric IDA patients whose renal functions and serum electrolytes were normal.eninfo:eu-repo/semantics/openAccessAnemiaEarly diagnosisIron-deficiencyKidney diseasesArticle2140234029WoSIDEksik2-s2.0-849523295302669789310.12659/MSM.896794Q1N/A