Screening of C2-symmetric chiral phosphinites as ligands for ruthenium(II)-catalyzed asymmetric transfer hydrogenation of prochiral aromatic ketones

Elma, DuyguDurap, FeyyazAydemir, MuratBaysal, AkinMeric, NerminAk, BunyaminTurgut, Yilmaz2024-04-242024-04-2420130022-328X1872-8561https://doi.org/10.1016/j.jorganchem.2013.01.012https://hdl.handle.net/11468/15723Metal-catalyzed transfer hydrogenation processes provide a widely-used alternative to direct hydrogenation processes of ketones. As part of an ongoing program, we report enantioselective C-2-symmetric bis(phosphinite)-ruthenium(II) catalytic systems for the transfer hydrogenation of prochiral aromatic ketones. The new catalytic systems can readily be formed under in situ conditions from C-2-symmetric chiral bis(phosphinite) ligands and [Ru(eta(6)-p-cymene)(mu-Cl)Cl](2) in transfer hydrogenation reaction media. These chiral ruthenium catalytic systems serve as catalyst precursors for the asymmetric transfer hydrogenation of acetophenone derivatives in iso-PrOH and giving the corresponding optical active secondary alcohols up to 94% ee. (C) 2013 Elsevier B.V. All rights reserved.eninfo:eu-repo/semantics/closedAccessCatalysisAsymmetric Transfer HydrogenationChiral Phosphinite LigandRutheniumC-2-SymmetryScreening of C2-symmetric chiral phosphinites as ligands for ruthenium(II)-catalyzed asymmetric transfer hydrogenation of prochiral aromatic ketonesScreening of C2-symmetric chiral phosphinites as ligands for ruthenium(II)-catalyzed asymmetric transfer hydrogenation of prochiral aromatic ketonesArticle7294652WOS:0003158036000072-s2.0-8487404996810.1016/j.jorganchem.2013.01.012Q2Q2