Yildirim, Ozgen AhmetPoyraz, KeremErdur, ErkanCan, CananGundogan, CihanGuzel, YunusEtem, Hulya2024-04-242024-04-2420210735-79071532-4192https://doi.org/10.1080/07357907.2021.1971241https://hdl.handle.net/11468/16784To evaluate ICIs related dry eye and dry mouth in nivolumab therapy, 24 patients receiving nivolumab (group 1), 30 patients in remission without treatment for 6 months (group 2), 30 healthy participants (group 3) were cross-sectionally examined. Schirmer's 1, 2, TSH blood tests, serological analysis, salivary flow scintigraphy and minor-salivary gland biopsy were performed. Schirmer's tests were performed with anesthetic (1) and without anesthetic (2). Schirmer's scores were lower in group 1 with more frequent reduced tear production (p < 0.001). TSH levels negatively correlated with Schirmer's scores. Functional insufficiency was detected by salivary flow scintigraphy in 7 out of 10 patients with Schirmer's test positivity. In Schirmer's positive patients, lymphocytic sialadenitis was confirmed in 4 patients (focus score > 1) and CD4 T lymphocyte precipitation was observed in 6 patients. Nivolumab therapy may be associated with ICIs related immune sicca.eninfo:eu-repo/semantics/openAccessReduced Tear ProductionNivolumabSchirmer'sArticle3910797807WOS:0006982725000013441581210.1080/07357907.2021.1971241Q4