Yucel, YavuzCoskun, SalihCengiz, BeyhanOzdemir, Hasan H.Uzar, ErtugrulCim, AbdullahCamkurt, M. Akif2024-04-242024-04-2420161738-10882093-4327https://doi.org/10.9758/cpn.2016.14.3.250https://hdl.handle.net/11468/20473Objective: Migraine, a highly prevelant headache disorder, is regarded as a polygenic multifactorial disease. Serotonin (5 HT) and their respective receptors have been implicated in the patogenesis. Methods: We investigated the 5-HT1A, 5-HT1B, 5-HT2A, and 5-HT2C receptor gene polymorphisms and their association with migraine in Turkish patients. The rs6295, rs1300060, rs1228814, rs6311, rs6313, rs6314, rs6318, rs3813929 (-759C/T) and rs518147 polymorphisms were analyzed in 135 patients with migraine and 139 healthy subjects, using a BioMark 96.96 dynamic array system. Results: We found no difference in the frequency of the analyzed eight out of nine polymorpisms between migraine and control groups. However, a significant association was found between the rs3813929 polymorphism in the promoter region of 5-HTR2C gene and migraine. Also, the allele of rs3813929 was more common in the migraine group. Conclusion: This result suggests that the 5-HTR2C rs3813929 polymorphism can be a genetic risk factor for migraine in a Turkish population.eninfo:eu-repo/semantics/openAccessMigraine DisordersSingle Nucleotide PolymorphismReceptor, Serotonin, 5-Ht2cGenetic Association StudiesHeadacheArticle143250255WOS:0003817800000032-s2.0-849884322232748937810.9758/cpn.2016.14.3.250Q2Q3