Akdag, MehmetAkkurt, Zeynep M.Gul, AylinUcmak, DeryaYilmaz, BeyhanSengul, EnginTopcu, Ismail2024-04-242024-04-2420140147-958X1488-2353https://hdl.handle.net/11468/21432Purpose: The purpose of this study was to investigate the effect of oral isotretinoin, a drug used in the treatment of acne vulgaris, on hearing function determined by serial audiology examinations. Methods: Forty patients with acne vulgaris were included in this study. Nine patients were excluded from the study because of inconsistent follow-up. The hearing of each participant was tested with pure tone audiometry and transient evoked autoacoustic emissions before and two and four weeks after treatment with isotretinoin (0.3-0.6 mg/kg/day) in the remaining 31 patients (62 ears). Results: Th e di ff erences between the mean values of the pre- treatment and post-treatment pure tone hearing thresholds at 1000, 2000, 4000 and 6000 Hz frequencies were statistically signi fi cant (p< 0.05), but there was no signi fi cant di ff erence between the pretreatment and post- treatment values at 250 and 500 Hz frequencies (p> 0.05). The difference between the pre-treatment and post-treatment signal-noise ratio values of the transient evoked autoacoustic emissions was not significantly different (p> 0.05). Conclusion: Our results suggest that the use of isotretinoin may cause bilateral hearing threshold changes. Further animal and human studies are required to investigate and characterize isotretinoin- induced neurophysiological alterations in hearing.eninfo:eu-repo/semantics/closedAccess[No Keyword]Article372E102E107WOS:0003342965000072-s2.0-8489865987324690417Q2Q4