Öztürk, GülşenÇolak, MehmetDemirel, Nadir2024-04-242024-04-242011Öztürk, G., Çolak, M. ve Demirel, N. (2011). Solvent-free synthesis of chiral Schiff-base ligands based on ferrocene under microwave irradiation and application to enantioselective nitroaldol (Henry) reaction. Chirality, 23(5), 374-378.0899-00421520-636Xhttps://doi.org/10.1002/chir.20934https://hdl.handle.net/11468/14012https://onlinelibrary.wiley.com/doi/10.1002/chir.20934Chiral Schiff-bases 3a-f based on ferrocene were designed and synthesized using solvent-free methods by mixing ferrocene carbaldehyde 1 with amino alcohols and amines 2a-f under microwave irradiation and classical method for the enantioselective nitroaldol (Henry) reaction. The Schiff-bases were obtained in shorter reaction times and improved yield under microwave irradiation method over classical method. The highest enantioselectivity was observed in ligand 3e (95% ee) when CH2Cl2 was used as solvent. Chirality 23: 374-378, 2011. (c) 2011 Wiley-Liss, Inc.eninfo:eu-repo/semantics/closedAccessFerroceneMicrowave irradiationChiral schiff-basesNitro aldol reactionHenry reactionArticle235374378WOS:0002896353000022-s2.0-799545318462148810410.1002/chir.20934Q2Q2