Genç, Çiğdem ÇetinGülsün, Belgin2022-10-032022-10-032021Genç, Ç. Ç. ve Gülsün, B. (2021). The effects of type-I collagen membrane, hydroxyapatite, and platelet-rich plasma on bone regeneration: An experimental study. International Dental Research, 11(Supplement 1), 96-102.2146-1767https://search.trdizin.gov.tr/yayin/detay/516756https://hdl.handle.net/11468/10595https://search.trdizin.gov.tr/yayin/detay/516756Aim: Various methods have been developed to support bone reconstruction, including the use of autogenous, allogenic, and synthetic bone graft substitutes, membranes, and concentrated supplements. This study aims to compare the effects of collagen membrane, hydroxyapatite, and platelet-rich plasma on the bone regeneration process in a rat model. Methodology: The experiment was conducted with 60 female Wistar albino rats. Subjects were divided randomly into three groups (n: 20). In the first group, the right femurs' defects were left empty (group I), and type-I collagen membrane was applied to the left femurs (group II). TypeI collagen membrane + hydroxyapatite (group III) was applied to the second group, and type-I collagen membrane + hydroxyapatite + platelet-rich plasma (PRP) (group IV) was applied to the third group. Thus, a total of 80 femurs were included in the study, and defects were evaluated histologically on the 10th, 21st, 45th, and 90th days (n: 5). Results: Groups II and III had better osteogenesis scores than group I, whereas group IV had better results than all other groups. Conclusion: In the PRP group, the osteogenesis scores were significantly better than the other groups. However, the healing was almost excellent in all three study groups (groups II, III, and IV) at the end of the experiment.eninfo:eu-repo/semantics/openAccessHydroxyapatiteType-I collagen membranePlatelet-rich plasmaBone regenerationOsteogenesisArticle11Supplement 19610251675610.5577/intdentres.2021.vol11.suppl1.16