Ayhan, ErhanKivrak, AbdullahAytekin, Sema2024-04-242024-04-2420111307-76351308-5255https://doi.org/10.5152/tdd.2011.18https://hdl.handle.net/11468/19995Biotinidase deficiency is impairment of biotin metabolism characterized by various dermatological, ophthalmic and neurological symptoms. Autosomal recessive trait is a disorder. Skin findings such as alopecia, periorificial dermatitis and seborrhoeic dermatitis lesions are seen. Clinical signs improved dramatically with biotine treatment. We presented a 6-year-old male patient with periorificial lesions, alopecia and microscopic hair shaft defects.trinfo:eu-repo/semantics/openAccessAlopeciaBiotinBiotinidase DeficiencyPeriorificial DermatitisArticle537981WOS:0004208730000042-s2.0-8035513245510.5152/tdd.2011.18Q4N/A