Alemdar, CelilYucel, IstemiErbil, BarisErdem, HavvaAtic, RamazanOzkul, Emin2024-04-242024-04-2420160019-54131998-3727https://doi.org/10.4103/0019-5413.185607https://hdl.handle.net/11468/19513Background: The common purpose of almost all methods used to treat the osteochondral injuries is to produce a normal cartilage matrix. However current methods are not sufficient to provide a normal cartilage matrix. For that reason, researchers have studied to increase the effectiveness of this methods using chondrogenic and chondroprotective molecules in recent experimental studies. Insulin-like growth factor-1 (IGF-1) and hyaluronic acid (HA) are two important agents used in this field. This study compared the effects of IGF-1 and HA in an experimental osteochondral defect in rat femora. Materials and Methods: The rats were divided into three groups ( n = 15 per group) as follows: The IGF-1 group, HA group, and control group. An osteochondral defect of a diameter of 1.5 mm and a depth of 2 mm was created on the patellar joint side of femoral condyles. The IGF-1 group received an absorbable gelatin sponge soaked with 15 g/15 l of IGF-1, and the HA group received an absorbable gelatin sponge soaked with 80 g HA. The control group received only an absorbable gelatin sponge. Rats were sacrificed at the 6 (th) week, and the femur condyles were evaluated histologically. Results: According to the total Mankin scale, there was a statistically significant difference between IGF-1 and HA groups and between IGF-1 and control groups. There was also a significant statistical difference between HA and control groups. Conclusion: It was shown histopathologically that IGF-1 is an effective molecule for osteochondral lesions. Although it is weaker than IGF-1, HA also strengthened the repair tissue.eninfo:eu-repo/semantics/openAccessCartilageHyaluronic AcidInsulin-Like Growth Factor-1Osteochondral Defect Mesh Terms: Hyaluronic AcidCartilageIgf-1Sports MedicineRatsEffect of insulin-like growth factor-1 and hyaluronic acid in experimentally produced osteochondral defects in ratsEffect of insulin-like growth factor-1 and hyaluronic acid in experimentally produced osteochondral defects in ratsArticle504414420WOS:0003812896000122-s2.0-849790101252751222410.4103/0019-5413.185607Q3Q4