Aldemir, MustafaGürel, AhmetBüyükbayram, HüseyinTaçyıldız, İbrahim2024-04-242024-04-242003Aldemir, M., Gürel, A., Büyükbayram, H. ve Taçyıldız, İ. (2003). The effects of glucose-insulin-potassium solution and BN 52021 in intestinal ischemia-reperfusion injury. Vascular and Endovascular Surgery, 37(5), 345-351.1538-5744https://doi.org/10.1177/153857440303700506https://hdl.handle.net/11468/23565The objective of this study was to investigate effects of glucose-insulin-potassium (GIK) solution and BN 52021, a platelet-activating factor antagonist, on intestinal ischemia-reperfusion injury. Fifty male Sprague-Dawley rats (200-225 g) were divided into 5 groups each containing 10 rats; group SO, sham operation group; group I, mesenteric ischemia group (for 30 minutes); group R, ischemia plus reperfusion (for 60 minutes); group BR, ischemia-reperfusion plus BN 52021; group GR, ischemia-reperfusion plus GIK solution. Samples for malondialdehyde (MDA) and ileum (for mucosal injury score) were obtained. The mucosal injury scores of group R were significantly higher than those of group I (4 ±0.20 and 3 ±0.16, respectively, p < 0.0001). The scores of groups BR and GR were significantly lower than those of group R (p < 0.0001 and p < 0.0001, respectively). When it was compared with the injuries in BR and GR groups, similar results were obtained in both groups (p = 0.190). Mean MDA levels of group R were significantly higher than those of group I, BR and GR (131.33 ±3.99 nmol/g, 93.74 ±3.22 nmol/g, 104.81 ±2.56 and 100.34 ±5.30, respectively, p < 0.0001). MDA levels of group BR and GR were significantly lower than those of group I (p < 0.0001 and p = 0.003, respectively). These observations suggest that treatment with GIK solution and BN 52021 before reperfusion and during reperfusion period may be useful in decreasing intestinal reperfusion injury.eninfo:eu-repo/semantics/closedAccessArticle3753453512-s2.0-01415231041452838010.1177/153857440303700506Q3