Ata Akil M.Acet H.Elbey M.A.Aydin M.Bilik Z.Yildiz A.Yuksel M.2024-04-242024-04-2420140393-6384https://hdl.handle.net/11468/25067Aim: To investigate the predisposing factors, demographic and clinical characteristics, echocardiographic and prognostic features, and outcomes of patients with native valve infective endocarditis (IE) in Turkey in a multicenter based study. Materials and methods: The study population consisted of 158 consecutive patients with native valve IE (NVE). Data on demographics, medical history, medications, clinical procedures, predisposing factors, clinical examination, microbiology, antibiotic therapy, echocardiography, surgery, complications, and outcome were collected and compared. Results: The mean age of the patients was 47±19 (range 13-87). Seventy seven patients (49%) were female. Of the 158 NVE patients, 49 died during hospitalization. Mortality rate was 31%. Twenty eight patients experienced a stroke. The patients who died during hospitalization were significantly older than the survivors and had higher mean heart rate, white blood cell, C reactive protein, creatinine, poor NYHA functional class, multiple vegetations and large vegetations. Culture-negative endocarditis was seen in 54 cases (34%). Staphylococci were the most common causative organisms (28%). Eighty patients had undergone surgical treatment (51%). Hemoglobin, presence of multiple vegetation, vegetation size (>10 mm), septic shock and poor NYHA class on admission were independent risks for in hospital mortality and stroke. Beside these variables C reactive protein was also an independent risk for in hospital mortality Conclusion: Native valve IE in Turkey was associated with high in-hospital mortality. Rheumatic heart disease continues to be the most common underlying heart condition and echocardiographic findings on admission were the most important independent predictors of mortality or stroke.eninfo:eu-repo/semantics/closedAccessMortalityNative Valve EndocarditiPrognostic FactorsArticle305103510392-s2.0-84944279216N/A